Protein folding ‐ seeing is deceiving

Protein interactions: is seeing believing?

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Is Protein Folding Sub-Diffusive?

Protein folding dynamics is often described as diffusion on a free energy surface considered as a function of one or few reaction coordinates. However, a growing number of experiments and models show that, when projected onto a reaction coordinate, protein dynamics is sub-diffusive. This raises the question as to whether the conventionally used diffusive description of the dynamics is adequate....

Protein folding is mechanistically robust.

Markov state models (MSMs) have proven to be useful tools in simulating large and slowly-relaxing biological systems like proteins. MSMs model proteins through dynamics on a discrete-state energy landscape, allowing molecules to effectively sample large regions of phase space. In this work, we use aspects of MSMs to ask: is protein folding mechanistically robust? We first provide a definition o...

Seeing more is seeing better.

Is protein folding hierarchic ? I . Local structure and peptide folding

ALTHOUGH SYNTHETIC ANALOGS of proteins might be developed ultimately, Flory’s succinct statement accurately summarizes the remarkable behavior of globular proteins. Today, an intense search is being made for the principles that guide the folding process. Although the work began with experimental studies (see Box 1), it has become increasingly clear that these results cannot be interpreted succe...